Essay topic 5. Neuromuscular junction as site of disease process. AND Formation of Nuromuscular junction.

Essay topic 5. 5. The neuromuscular occasion as a post of disease process Proteins involved in defining of the neuromuscular adjunction The neuromuscular junction is a particularize junction, where a ram marrow forms its synaptic terminal with a muscle character reference, one of umteen fibres that make up a whole muscle. The mature neuromuscular junction is composed of cardinal types of mobile phones - a motor kernel terminal, a muscle fibre and a Schwann cell c all(prenominal) over the junction. each(prenominal) three of these cells argon highly differentiated and specialized for their functions (Kandel 2000, p. 1089). The events that materialize during the formation of the neuromuscular junction have been extensively analyze and are the most comprehensively understood of any nerve-to-tar beget cell contact. Prior to formation of the synapse all three components of the neuromuscular junction develop and acquire identities independently. The muscle cells are derived from the mesoderm and migrate from the dermomyotomal portion of the somite. Motoneurons migrate from the ventricular zone of the neural metro to a ventral-lateral location before axons grow out of the spinal anesthesia anaesthesia anesthesia cord. Schwann cells are glial cells, which insulate the axons outside of the spinal cord, they are derived from neural crest cells and associate with axons from the somite forward to the peripheral device target.

At the time of the first axons arrive at the developing muscle, the muscle fibres are myoblasts that have just fused to form multinucleated myotubes, t here is no evidence to suggest that motor ne! urons prefer certain situate on the developing myotube or that there is a determine site for the formation of the synapse, on the contrary, synapse formation can occur on most, if not all of the myotube surface (Lichtman et al in Zigmond et al 2000, pp. 547-8). Acetylcholine receptors (AChR) are put together uniformly dispersed over the surface of the... If you want to get a full essay, ordinate it on our website: OrderCustomPaper.com

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